Some studies have compared the effectiveness of these two kinds of therapy for unexplained infertility. Pregnancy rate is improved substantially with either kind of therapy as compared to lack of therapy.

The chance of pregnancy is better with in vitro fertilization as compared to gonadotropin medication plus in vivo insemination. However, IVF is more invasive, complicated and expensive than in vivo insemination. Unless the infertile couple suffers from tubal damage or very poor sperm quality, 3-4 insemination cycles are usually attempted before initiating IVF technique.