The in vivo artificial insemination (AI) is commonly used for endometriosis, unexplained infertility, lack of ovulation (anovulation), mild - moderate degree of male factor infertility, cervical factor infertility, or couples with immunological abnormalities.

It is a valuable treatment and should be applied for about 3-6 months in women who can ovulate by their own.

It can be used for a period of longer than 6 ovulation cycles with a status of female or male sub-fertility, patient with an ovulation that has been medicated to ovulate successfully.